Our Scientific Publications

We have a long standing expertise in Spinal Muscular Atrophy and other neurological diseases. Here, you find our Scientific Publications. Many of those have been developed in collaboration with our scientists.

Sabrina Kubinski & Peter Claus (2022): Protein Network Analysis Reveals a Functional Connectivity of Dysregulated Processes in ALS and SMA. Neuroscience Insights, in press.

Lars Klimaschewski and Peter Claus (2021): Fibroblast growth factor signalling in the diseased nervous system. Molecular Neurobiology 58(8):3884-3902.

Veronika J.M. Breitkopf, Gerhard Dobler, Peter Claus, Hassan Y. Naim, Imke Steffen (2021): IRE1-mediated unfolded protein response promotes the replication of tick-borne flaviviruses in a virus- and cell-type dependent manner. Viruses 13: 2164. doi: 10.3390/v13112164

Lisa Marie Walter, Sebastian Rademacher, Andreas Pich, and Peter Claus (2021): Profilin2 regulates actin rod assembly in neuronal cells. Scientific Reports, 11: 10287.

Niko Hensel, Pamela Santonicola, Federica Cieri, Ines Marlene Tapken, Tobias Schüning, Michela Taiana, Elisa Pagliari, Antonia Joseph, Silke Fischer, Natascha Heidrich, Hella Brinkmann, Sabrina Kubinski, Anke Katharina Bergmann, Manuela Friederike Richter, Klaus Jung, Stefania Corti, Elia Di Schiavi*, Peter Claus* (2021): Impairment of the neurotrophic signaling hub B-Raf contributes to motoneuron degeneration in Spinal Muscular Atrophy. PNAS 118(18):e2007785118.
*contributed equally as senior authors.

Niko Hensel, Sabrina Kubinski and Peter Claus (2020): The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs. Front. Neurology 11: 45. doi: 10.3389/fneur.2020.00045

Gamze Bora, Niko Hensel, Sebastian Rademacher, Dila Koyunoğlu, Merve Sunguroğlu, Evrim Aksu-Mengeş, Burcu Balci-Hayta, Peter Claus, Hayat Erdem-Yurter (2020): Microtubule associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in Spinal Muscular Atrophy. Hum. Mol. Gen. 29: 3935-3944.

Sebastian Rademacher, Nora T. Detering, Tobias Schüning, Robert Lindner, Pamela Santonicola, Inga-Maria Wefel, Janina Dehus, Lisa M. Walter, Hella Brinkmann, Agathe Niewienda, Katharina Janek, Miguel A. Varela, Melissa Bowerman, Elia Di Schiavi, and Peter Claus (2020): A single amino acid residue regulates PTEN-binding and stability of the Spinal Muscular Atrophy protein SMN. Cells 9: 2405.

Niko Hensel, Verena Raker, Benjamin Förthmann, Anna Buch, Beate Sodeik, Andreas Pich and Peter Claus (2020): The proteome and secretome of cortical brain cells infected with herpes simplex virus. Front. Neurol 11:844.

Niko Hensel, Hermann Brickwedde, Konstantinos Tsaknakis, Antonia Grages, Lena Braunschweig, Katja A Lüders, Heiko Matthias Lorenz, Sebastian Lippross, Lisa Marie Walter, Frank Tavassol, Stefan Lienenklaus, Claudia Neunaber, Peter Claus#, and Anna Kathrin Hell# (2020): Altered bone development with impaired cartilage formation precedes neuromuscular symptoms in Spinal Muscular Atrophy (SMA). #, contributed equally as senior authors. Hum. Mol. Gen. 29: 2662-2673.

Hazel Allardyce, Daniela Kuhn, Elena Hernandez-Gerez, Niko Hensel, Yu-Ting Huang, Kiterie Faller, Thomas H. Gillingwater, Fabio Quondamatteo, Peter Claus, Simon H. Parson (2020): Renal pathology in a mouse model of severe Spinal Muscular Atrophy is associated with downregulation of Glial Cell-Line Derived Neurotrophic Factor (GDNF). Hum. Mol. Gen. 29: 2365–2378.

Nina Ahlskog, Daniel Hayler, Anja Krueger, Sabrina Kubinski, Peter Claus, Suzan M. Hammond, Matthew JA Wood, Rafael J Yáñez-Muñoz, Melissa Bowerman (2020): Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice. Gene Therapy 27: 505-515.

Niko Hensel, Nora Tula Detering, Lisa Walter, and Peter Claus (2020): Resolution of pathogenic R-loops rescues motoneuron degeneration in Spinal Muscular Atrophy. Brain 143: 2-5. doi: 10.1093/brain/awz394.

Frank Brand, Alisa Förster, Anne Christians, Martin Bucher, Carina Thomé, Marc S. Raab, Manfred Westphal, Torsten Pietsch, Andreas von Deimling, Guido Reifenberger, Peter Claus, Bettina Hentschel, Michael Weller, Ruthild G. Weber (2020): FOCAD loss is associated with decreased survival in astrocytic glioma, impacts microtubules and G2/M progression. Acta Neuropathologica 139: 175-192. doi: 10.1007/s00401-019-02067-z

Lisa Marie Walter, Peter Franz, Robert Lindner, Georgios Tsiavaliaris, Niko Hensel, Peter Claus (2020): Profilin2a-phosphorylation as a regulatory mechanism for actin dynamics. FASEB J. 34: 2147-2160. doi:10.1096/fj.201901883R

Niko Hensel*, Verena Raker*, Benjamin Förthmann, Nora-Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi8, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, and Peter Claus (2019): HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. Journal of Neuroinflammation 16: 248. doi: 10.1186/s12974-019-1647-5.
*contributed equally.

Gamze Bora, Caren Sucularli, Niko Hensel, Peter Claus, Hayat Erdem Yurter (2019): Investigations of Microtubule-associated Protein 2 Gene Expression in Spinal Muscular Atrophy. J. Pediatr. Res. 6: 148-154.

Marc-Olivier Deguise, Giovanni Baranello, Chiara Mastella, Ariane Beauvais, Jean Michaud, Alessandro Leone, Ramona De Amicis, Alberto Battezzati, Christopher Dunham, Kathryn Selby, Jodi Warman Chardon, Hugh J McMillan, Yu-Ting Huang, Natalie L. Courtney, Alannah J. Mole, Sabrina Kubinski, Peter Claus, Lyndsay M. Murray, Melissa Bowerman, Thomas H. Gillingwater, Simona Bertoli, Simon H. Parson, and Rashmi Kothary, PhD (2019): Abnormal fatty acid metabolism is a core component of spinal muscular atrophy. Annals of Clinical and Translational Neurology, 6:1519-1532.

Bianca Schröder-Heurich, Sandra von Hardenberg, Lars Brodowski, Berina Kipke, Katja Borns, Constantin S. von Kaisenberg, Hella Brinkmann, Peter Claus, Frauke von Versen-Höynck (2019): Vitamin D improves endothelial barrier integrity and counteracts inflammatory effects on endothelial progenitor cells. FASEB J. 33: 9142-9153.

Hensel N. & Claus P. (2018): The actin cytoskeleton in SMA and ALS: How does it contribute to motoneuron degeneration? Neuroscientist 24: 54-72.

Robin Kosch, Julien Delarocque, Peter Claus, Stefanie C. Becker and Klaus Jung (2018): Gene expression profiles in neurological tissues during West Nile virus infection: a critical meta-analysis. BMC Genomics, 19(1): 530.

Lisa M Walter, Christiane E Koch, Corinne A Betts, Nina Ahlskog, Katharina E Meijboom, Tirsa LE van Westering, Gareth Hazell, Amarjit Bhomra, Peter Claus, Henrik Oster, Matthew JA Wood, Melissa Bowerman (2018): Light modulation improves circadian dysregulation and phenotype in spinal muscular atrophy mice. Human Molecular Genetics 27: 3582-3597.

Lisa Marie Walter, Marc-Olivier Deguise, Katharina E Meijboom, Corinne A Betts, Nina Ahlskog, Tirsa LE van Westering, Gareth Hazell, Emily McFall, Anna Kordala, Suzan M Hammond, Frank Abendroth, Lyndsay M Murray, Hannah K Shorrock, Domenick A Prosdocimo, Saptarsi M Haldar, Mukesh K Jain, Thomas H Gillingwater, Peter Claus, Rashmi Kothary, Matthew JA Wood, Melissa Bowerman (2018): Interventions targeting glucocorticoid-Krüppel-like factor 15-branched-chain amino acid signaling improve disease phenotypes in spinal muscular atrophy mice. EBioMedicine 31: 226-242.

Uhde AK, Ciurkiewicz M, Herder V, Akram Khan M, Hensel N, Claus P, Beckstette M, Teich R., Floess S., Baumgärtner W, Jung K, Huehn J, Beineke A (2018): Intact interleukin-10 receptor signaling protects from hippocampal damage following experimental neurotropic virus infection of SJL mice. Scientific Reports 8: 6106.

Balek L, Buchtova M, Kunova Bosakova M, Varecha M, Foldynova-Trantirkova S, Gudernova I1, Vesela I, Havlik J, Neburkova J, Turner S, Krzyscik MA, Zakrzewska M, Klimaschewski L, Claus P, Trantirek L, Cigler P, Krejci P (2018): Nanodiamonds as artificial proteins: regulation of cell signaling system using picomolar solutions of inorganic nanocrystals. Biomaterials 176: 106-121.

Rademacher S., Verheijen B.M., Hensel N., Peters M., Bora G., Brandes G., Vieira de Sá R., Heidrich N., Fischer S., Brinkmann H., van der Pol W.L., Wirth B., Pasterkamp R.J., Claus P. (2017): Metalloprotease-mediated cleavage of PlexinD1 and its sequestration to actin rods in the motoneuron disease Spinal muscular atrophy (SMA). Human Molecular Genetics 26: 3946-3959.

Hensel N., Baskal S., Brinkmann H., Gernert M., Claus P. (2017): ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy. Neurobiol. Dis. 108: 352-361.

Stanslowsky N., Reinhardt P., Glass H., Kalmbach N., Naujock M., Hensel N., Lübben V., Pal A., Venneri A., Lupo F., De Franceschi L., Claus P., Sterneckert J., Storch A., Hermann A., Wegner F. (2016): Neuronal dysfunction in iPSC-derived medium spiny neurons from Chorea-Acanthocytosis patients is reversed by Src-kinase inhibition and F-actin stabilization. J. Neurosci. 36:12027–12043.

Hensel N.*, Schön A.,*, Konen T.*, Lübben V., Förthmann B., Baron O., Grothe C., Leifheit-Nestler M.#, Claus P.#, Haffner D.# (2016): Fibroblast growth factor 23 acting on hippocampal neurons: Impact on neuronal morphology and synaptic density. J. Neurochem., 137:756-69. DOI: 10.1111/jnc.13585.
*Contributed equally as first authors; #contributed equally as senior authors.

Rumpel R.*, Baron O.*, Ratzka A.*, Schröder M.-L., Hohmann M, Effenberg A., Claus P., Grothe C. (2016): Innervation of forebrain targets by midbrain dopaminergic neurons depends on FGF signaling. Neuroscience 314: 134-144.
*First authors contributed equally.

Hensel N., Rademacher S., Claus P. (2015): Chatting with the neighbors: Crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders. Front. Neurosci. 9:198. doi: 10.3389/fnins.2015.00198.

Förthmann B., Grothe C., Claus P. (2015): A nuclear odyssey: Fibroblast Growth Factor -2 (FGF-2) as a regulator of nuclear homeostasis in the nervous system. Cell. Mol. Life Sci. 72: 1651- 1662.

Li S., Payne S., Wang F., Claus P., Su Z., Groth J., Geradts J., de Ridder G., Alvarez R., Marcom P.K., Pizzo S.V., Bachelder R.E. (2015): Nuclear basic fibroblast growth factor regulates triple-negative breast cancer chemo-resistance. Breast Cancer Research 17: 91.

Förthmann B., Aletta J., Lee Y.-W., Terranova C., Birkaya B., Stachowiak E., Stachowiak M.K., Claus P. (2015): Coalition of nuclear receptors in the nervous system. J. Cell. Physiol. 230: 2875-2880. doi: 10.1002/jcp.25036.

Hensel N., Stockbrügger I., Rademacher S., Broughton N., Brinkmann H., Grothe C., Claus P. (2014): Bilateral Crosstalk of Rho- and Extracellular-Signal-Regulated -Kinase (ERK) Pathways is Confined to an Unidirectional Mode in Spinal Muscular Atrophy (SMA). Cellular Signalling 26: 540-548.

Förthmann B., van Bergeijk B., Lee Y.W., Lübben V., Schill Y., Brinkmann H., Ratzka A., Stachowiak M.K., Hebert M, Grothe C., Claus P. (2013): Regulation of neuronal differentiation by proteins associated with nuclear bodies. PLoS One 8(12):e82871. doi: 10.1371/journal.pone.0082871

Sun H., Bénardais K., Stanslowsky N., Thau N., Hensel N., Huang D., Claus P., Dengler R., Stangel M., Petri S. (2013): Therapeutic potential of mesenchymal stromal cells and MSC conditioned medium in Amyotrophic Lateral Sclerosis (ALS) - In vitro evidence from primary motor neuron cultures, NSC-34 cells, astrocytes and microglia. PLoS One 8(9): e72926.

Müller M., Diensthuber R.P., Chizhov I., Claus P., Heissler S.M., Preller M., Taft M.H., Manstein D.J. (2013): Distinct functional interactions between actin isoforms and nonsarcomeric myosins. PLoS One 8(7): e70636. doi:10.1371/journal.pone.0070636.

Lee Y.W., Stachowiak E.K., Birkaya B., Terranova C., Capacchietti M., Claus P., Aletta J.M., Stachowiak M.K. (2013): NGF-Induced Cell Differentiation and Gene Activation Is Mediated by Integrative Nuclear FGFR1 Signaling (INFS). PLoS One. 2013 8: e68931. doi: 10.1371/journal.pone.0068931.

Förthmann B., Brinkmann H., Ratzka R., Stachowiak M.K., Grothe C., Claus P. (2013): Immobile survival of motoneuron (SMN) protein stored in Cajal bodies can be mobilized by protein interactions. Cell. Mol. Life Sci. 70: 2555–2568.

Irschick R., Trost T., Karp G., Hausott B., Auer M., Claus P., Klimaschewski L. (2013): Sorting of the FGF receptor 1 in a human glioma cell line. Histochem. Cell Biol., 139: 135-148.

Baron O., Förthmann B.$, Lee Y.W.$, Terranova C.$, Ratzka A., Stachowiak E.K., Grothe C., Claus P.*, Stachowiak M.K.* (2012): Cooperation of nuclear FGFR1 and Nurr1 offers a new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons. Journal of Biological Chemistry 287: 19827-19840.

Lee Y.W., Terranova C., Birkaya B., Narla S., Kehoe D., Parikh A., Dong S., Ratzka A., Brinkmann H., Aletta J.M., Tzanakakis E.S., Stachowiak E.K., Claus P.*, Stachowiak M.K.* (2012): A novel nuclear FGF Receptor-1 partnership with retinoid and Nur receptors during developmental gene programming of embryonic stem cells. J. Cell. Biochem. 113: 2920-2936. 2.9
*These senior authors are both corresponding authors.

Claus P. (2012): Pathogenese der Spinalen Muskelatrophie. Klin. Neurophysiol. 43: 203-205.

Bosio Y., Berto G., Camera P., Bianchi F., Ambrogio C., Claus P., Di Cunto F. (2012): PPP4R2 regulates neuronal cell differentiation and survival, functionally cooperating with SMN. European Journal of Cell Biology 22: 454-471.

Hensel N., Ratzka A., Brinkmann H., Klimaschewski L., Grothe C., Claus P. (2012): Analysis of the Fibroblast Growth Factor system reveals alterations in a mouse model of Spinal Muscular Atrophy. PLoS One 7: e31202.

Jungnickel J., Eckhardt M., Haastert-Talini K., Claus P., Bronzlik P., Walnik L., Lipokatic-Takacs E., Kuhlemann K., Maier H., Gieselmann V., Grothe C. (2012): Polysialyltransferase-overexpression in Schwann cells mediates different effects during peripheral nerve regeneration. Glycobiology 22: 107-115.

Nölle A., Zeug A., van Bergeijk J., Tönges L., Gerhard R., Brinkmann H., Al Rayes S., Hensel N., Schill Y., Apkhazava D., Jablonka S., O´mer J., Srivastav R.K., Baasner A., Lingor P., Wirth B., Ponimaskin E., Niedenthal R., Grothe C., Claus P. (2011): The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Human Molecular Genetics 20: 4865-4878.

Kreutzer M., Seehusen F., Kreutzer R., Pringproa K., Kummerfeld, M., Claus P., Deschl U., Kalkul A., Beineke A., Baumgärtner W., Ulrich R. (2011): Axonopathy is associated with complex axonal 1 transport defects 2 in a model of multiple sclerosis. Brain Pathol. 22: 454-71.

Heurich B., Bahia el Idrissi N., Donev R.M., Petri S., Claus P., Neal J., Morgan B.P., Ramaglia V. (2011): Complement upregulation and activation on motor neurons and neuromuscular junction in the SOD1 G93A mouse model of familial Amyotrophic Lateral Sclerosis. J. Neuroimmunology 235:104-109.

Nobre A., Kalve I., Cesnulevicius K., Rangancokova D., Ratzka A., Halfer N., Wesemann M., Krampfl K., Claus P., Grothe C. (2010): Characterization and differentiation potential of rat ventral mesencephalic neuronal progenitor cells immortalized with SV40 large T antigen. Cell Tissue Res. 340:29-43.

Jungnickel J., Haastert K., Grzybek M., Thau N., Lipokatic-Takacs E., Ratzka A., Nölle A., Claus P., Grothe C. (2010): Mice lacking basic fibroblast growth factor showed faster sensory recovery. Exp. Neurol. 223:166-72.

Please, contact us for questions about our publications.